常州市存仁生物工程有限公司

487.42

C₂₅H₂₈Cl₂N₄O₂

1431697-89-0

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US; may vary elsewhere

10 mM in DMSO

OTSSP167 is prepared in vehicle (PBS)^[4].

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

• [1]. Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.

  [2]. Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.

  [3]. Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11.

  [4]. Li S, et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer. Oncotarget. 2016 Feb 2;7(5):6266-80.