Chemren Bio-Engineering Co., Ltd.

4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs.
IC50 value:
Target: HDAC1/2/3
The novel HDACi 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes. It has shown substantial anti-tumour activity in a broad panel of cancer cell lines as well as in various cancer xenograft models. A Phase I study with 4SC-202 in haematological malignancies is currently prepared and about to start soon

[1]. S.W.Henning, et al. Preclinical characterization of 4SC-202, a noval isotype specific HDAC inhibitor