Biological Activity
PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
| Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
| Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
| Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by |
Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
| Molecular Weight |
369.22 |
| Formula |
C17H13BrN4O |
| CAS Number |
194423-15-9 |
| Purity |
>98% |
| Solubility |
DMSO 60 mg/mL |
| Storage |
at -20°C |
| Chemical Name |
2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- |
Availability and price:
Stock : in stock
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For quotation, question, and order, please send email to :sales@chemrenpharm.com 
Antibody-drug Conjugate/ADC Related
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