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Product name : Palomid 529(P529)
Item : CR1077
CAS : 914913-88-5
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| Details: |
Description of:Palomid 529 (P529)
Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. Palomid 529 (P529) inhibits tumor growth, angiogenesis, and vascular permeability. However, Palomid 529 (P529) has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 (P529) inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. Theoretical analysis:Palomid 529 (P529) M.Wt: 406.43 Formula: C24H22O6 Solubility: Unknown Purity: >99% Storage: at -20℃ 2 years CAS No: 914913-88-5 Availability and price:Palomid 529 (P529) Pakage：10mg/25mg/100mg/250mg/500mg/1g/5g Stock : in stock We offer significant discount for larger quantity order. For quotation, question, and order, please send email to : sales@chemrenpharm.com Quality control data: Quality Control by H-NMR,C-NMR,LC-MS,HPLC. Product will be shipped with supporting analytical data. Fast delivery about 4-5 working days |
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